Роль биомаркеров мочи в диагностике туберкулеза легких (обзор)
DOI:
https://doi.org/10.37482/2687-1491-Z138Ключевые слова:
метаболомный анализ, масс-спектрометрия MALDI-TOF,, диагностика туберкулеза, предикторы эффективности лечения туберкулеза, хемокин IP-10, трансренальная ДНК, биомаркеры мочиАннотация
Диагностика туберкулеза на основе анализа мокроты имеет ограничения для отдельных категорий пациентов (пожилые люди, дети, лица, живущие с ВИЧ). Альтернативным методом может быть ускоренный поиск биомаркеров заболевания в моче, при котором возможно получение большего объема материала неинвазивным путем. Проведен поиск публикаций на английском языке в базах данных PubMed и Cochrane Library, опубликованных с 2010 по 2021 год, с использованием терминов tuberculosis + urine + biomarkers. Работы, посвященные анализу липоарабиноманнана в моче, исключены из данного обзора в связи с изученностью темы. В рассмотренных публикациях представлено более 30 биомаркеров мочи, используемых для диагностики туберкулеза и оценки эффективности противотуберкулезной терапии. Активно продолжает изучаться экстракция микобактериальной трансренальной ДНК из мочи, но чувствительность и специфичность диагностики зависят от метода экстракции и ВИЧ-статуса пациента. Биомаркер туберкулеза IP-10, вероятно, является неспецифическим маркером воспаления, однако его уровень коррелирует с ВИЧ-статусом и может быть полезен для оценки ответа на противотуберкулезное лечение. Показан потенциал метаболомных биомаркеров и биосигнатур в оценке активности туберкулезного процесса и дифференциальной диагностике туберкулеза с другими респираторными заболеваниями. Количество достоверных биомаркеров для прогнозирования результатов лечения туберкулеза ограничено. В многочисленных нецелевых исследованиях масс-спектроскопический анализ использовался для выявления метаболомных и протеомных биомаркеров в моче. Представленные работы отличались по дизайну и методам исследования, лишь некоторые публикации содержали анализ специфичности и чувствительности рассматриваемых методов диагностики. В будущем комбинация биомаркеров хозяина и патогена может повысить чувствительность и специфичность диагностики туберкулеза.
Скачивания
Библиографические ссылки
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Drobniewski F., Nikolayevskyy V., Maxeiner H., Balabanova Y., Casali N., Kontsevaya I., Ignatyeva O. Rapid Diagnostics of Tuberculosis and Drug Resistance in the Industrialized World: Clinical and Public Health Benefits and Barriers to Implementation // BMC Med. 2013. Vol. 11. Art. № 190. DOI: 10.1186/1741-7015-11-190
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References
Global Tuberculosis Report 2021. World Health Organization. Geneva, 2021. 57 p.
Drobniewski F., Nikolayevskyy V., Maxeiner H., Balabanova Y., Casali N., Kontsevaya I., Ignatyeva O. Rapid Diagnostics of Tuberculosis and Drug Resistance in the Industrialized World: Clinical and Public Health Benefits and Barriers to Implementation. BMC Med., 2013, vol. 11. Art. no. 190. DOI: 10.1186/1741-7015-11-190
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Lateral Flow Urine Lipoarabinomannan Assay (LF-LAM) for the Diagnosis of Active Tuberculosis in People Living with HIV. Policy Update 2019. World Health Organization. Geneva, 2019. 44 p.
Fernández-Carballo B.L., Broger T., Wyss R., Banaei N., Denkinger C.M. Toward the Development of a Circulating Free DNA-Based in vitro Diagnostic Test for Infectious Diseases: A Review of Evidence for Tuberculosis. J. Clin. Microbiol., 2019, vol. 57, no. 4. Art. no. e01234-18. DOI: 10.1128/JCM.01234-18
Oreskovic A., Brault N.D., Panpradist N., Lai J.J., Lutz B.R. Analytical Comparison of Methods for Extraction of Short Cell-Free DNA from Urine. J. Mol. Diagn., 2019, vol. 21, no. 6, pp. 1067–1078. DOI: 10.1016/j.jmoldx.2019.07.002
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Petrone L., Cannas A., Vanini V., Cuzzi G., Aloi F., Nsubuga M., Sserunkuma J., Nazziwa R.A., Jugheli L., Lukindo T., Girardi E., Antinori A., Pucci L., Reither K., Goletti D. Blood and Urine Inducible Protein 10 as Potential Markers of Disease Activity. Int. J. Tuberc. Lung Dis., 2016, vol. 20, no. 11, pp. 1554–1561. DOI: 10.5588/ijtld.16.0342
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Isa F., Collins S., Lee M.H., Decome D., Dorvil N., Joseph P., Smith L., Salerno S., Wells M.T., Fischer S., Bean J.M., Pape J.W., Johnson W.D., Fitzgerald D.W., Rhee K.Y. Mass Spectrometric Identification of Urinary Biomarkers of Pulmonary Tuberculosis. EBioMedicine, 2018, vol. 31, pp. 157–165. DOI: 10.1016/j.ebiom.2018.04.014
Deng J., Liu L., Yang Q., Wei C., Zhang H., Xin H., Pan S., Liu Z., Wang D., Liu B., Gao L., Liu R., Pang Y., Chen X., Zheng J., Jin Q. Urinary Metabolomic Analysis to Identify Potential Markers for the Diagnosis of Tuberculosis and Latent Tuberculosis. Arch. Biochem. Biophys., 2021, vol. 704. Art. no. 108876. DOI: 10.1016/j.abb.2021.108876
Liu L., Deng J., Yang Q., Wei C., Liu B., Zhang H., Xin H., Pan S., Liu Z., Wang D., Pang Y., Chen X., Gao L., Zheng J., Liu R., Jin Q. Urinary Proteomic Analysis to Identify a Potential Protein Biomarker Panel for the Diagnosis of Tuberculosis. IUBMB Life, 2021, vol. 73, no. 8, pp. 1073–1083. DOI: 10.1002/iub.2509
Dang N.A., Janssen H.-G., Kolk A.H. Rapid Diagnosis of TB Using GC-MS and Chemometrics. Bioanalysis, 2013, vol. 5, no. 24, pp. 3079–3097. DOI: 10.4155/bio.13.288
Sandlund J., Lim S., Queralto N., Huang R., Yun J., Taba B., Song R., Odero R., Ouma G., Sitati R., Murithi W., Cain K.P., Banaei N. Development of Colorimetric Sensor Array for Diagnosis of Tuberculosis Through Detection of Urinary Volatile Organic Compounds. Diagn. Microbiol. Infect. Dis., 2018, vol. 92, no. 4, pp. 299–304. DOI: 10.1016/j.diagmicrobio.2018.06.014
Russell T.M., Green L.S., Rice T., Kruh-Garcia N.A., Dobos K., De Groote M.A., Hraha T., Sterling D.G., Janjic N., Ochsner U.A. Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications. J. Clin. Microbiol., 2017, vol. 55, no. 10, pp. 3072–3088. DOI: 10.1128/JCM.00469-17
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Kim S.H., Lee N.-E., Lee J.S., Shin J.H., Lee J.Y., Ko J.-H., Chang C.L., Kim Y.-S. Identification of Mycobacterial Antigens in Human Urine by Use of Immunoglobulin G Isolated from Sera of Patients with Active Pulmonary Tuberculosis. J. Clin. Microbiol., 2016, vol. 54, no. 6, pp. 1631–1637. DOI: 10.1128/JCM.00236-16
Eribo O.A., Leqheka M.S., Malherbe S.T., McAnda S., Stanley K., van der Spuy G.D., Walzl G., Chegou N.N. Host Urine Immunological Biomarkers as Potential Candidates for the Diagnosis of Tuberculosis. Int. J. Infect. Dis., 2020, vol. 99, pp. 473–481. DOI: 10.1016/j.ijid.2020.08.019
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