Physiological Bases of Goal-Directed Fluid Therapy in Cardiac Surgery (Review)

Authors

DOI:

https://doi.org/10.37482/2687-1491-Z133

Keywords:

cardiac surgery, fluid therapy, fluid responsiveness, fluid challenge, passive leg raise, cardiac output, volume status

Abstract

Goal-directed fluid therapy is a paradigm in perioperative medicine, which includes haemodynamic monitoring and individualized haemodynamic management in high-risk patients by means of fluid therapy. This approach has certain benefits compared with the traditional model of fluid therapy during the perioperative period of cardiac surgery. The required fluid volume can be hard to determine. Traditionally, fluid therapy was guided by static preload parameters, such as central venous pressure and
pulmonary artery occlusion pressure, which failed to provide adequate precision. In opposition to static parameters, a number of dynamic indices and tests were developed to assess fluid responsiveness. The cornerstone of dynamic indices are cyclic preload changes due to intrathoracic pressure variations during mechanical ventilation. Dynamic tests are circulatory stress tests involving preload changes. The most frequently used tests are passive leg raise, fluid challenge test, and some others. However, in spite of their satisfactory predictive value, dynamic indices and tests have certain limitations, which must be taken into consideration. For instance, mechanical ventilation, sinus rhythm, intact thorax, and normal respiratory mechanics are obligatory conditions for applying dynamic indices. Thus, using dynamic indices can be difficult in cardiac surgery, making the search for new methods to overcome their limitations highly important.

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Author Biographies

Dmitriy A. Volkov, Northern State Medical University, City Clinical Hospital No. 1 named after E.E. Volosevich

Arkhangelsk, Russian Federation

Mikhail Yu. Kirov, Northern State Medical University, City Clinical Hospital No. 1 named after E.E. Volosevich

Arkhangelsk, Russian Federation

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Published

2023-02-03

How to Cite

Volkov Д., & Kirov М. (2023). Physiological Bases of Goal-Directed Fluid Therapy in Cardiac Surgery (Review). Journal of Medical and Biological Research, 11(1), 108–121. https://doi.org/10.37482/2687-1491-Z133