Activity of Heterocyclic Tellurium Derivatives Against Opportunistic Bacteria
DOI:
https://doi.org/10.37482/2687-1491-Z200Keywords:
organotellurium compounds, antibacterial properties, minimum inhibitory concentration, minimum suppressive concentration, Staphylococcus aureus, Escherichia coli, SalmonellaAbstract
Antimicrobial resistance is a serious challenge for medicine and society as a whole. Among the bacteria that pose the greatest threat to human health due to their growing antibiotic resistance are Escherichia coli, Staphylococcus aureus and Salmonella spp. The main reasons behind this problem are the misuse of antibiotics and lack of new antimicrobials, which are difficult to develop due to the complexity of the mechanisms of microbial infections and their limited weak points. Moreover, the process of developing new drugs requires significant time and financial resources. The purpose of this article was to analyse the antibacterial properties of three tellurium derivatives against infections caused by E. coli, S. aureus and Salmonella spp. Materials and methods. During the experiment, we studied the antimicrobial activity against the abovementioned bacteria of the following organotellurium compounds of original synthesis that have not been previously described in literature: dioxyrocyclo-[4-methylphenyl] tellurochloride, 3-chloromethyl-dioxisinrocyclophenyl tellurochloride, and ethyltellurobenzal-[2-methoxy-3,5-dichloro] aniline. As a criterion for the microorganism’s sensitivity to organotellurium compounds, inhibition zone diameter was used. The paper applied the serial dilution method and the
disk diffusion method. Results. The study of the three heterocyclic tellurium derivatives in various concentrations revealed a significant antibacterial effect of dioxyrocyclo-[4-methylphenyl] tellurochloride, whose minimum suppressive and minimum inhibitory concentrations against the bacteria in question we were able to determine. Minimum inhibitory concentrations for E. coli and S. aureus were 18.60 and 1.35 µg/ml, respectively. Disk diffusion showed that the inhibition zones range between 3 and 6 mm. E. coli and S. aureus strains were particularly sensitive to this compound. Ethyltellurobenzal-[2-methoxy-3,5-dichloro] aniline failed to produce a positive effect against E. coli, S. aureus and Salmonella spp. at any regimen, while 3-chloromethyl-dioxisinrocyclophenyl tellurochloride demonstrated moderate antimicrobial activity at a relatively low bacterial load.
Downloads
References
Vávrová S., Struhárňanská E., Turňa J., Stuchlík S. Tellurium: A Rare Element with Influence on Prokaryotic and Eukaryotic Biological Systems // Int. J. Mol. Sci. 2021. Vol. 22, № 11. Art. № 5924. https://doi.org/10.3390/ijms22115924
Burkholz T., Jacob C. Tellurium in Nature // Encyclopedia of Metalloproteins / ed. by R.H. Kretsinger, V.N. Uversky, E.A. Permyakov. N. Y.: Springer, 2013. P. 2163–2174.
Jeje O., Ewunkem A.J., Jeffers-Francis L.K., Joseph L.G. Jr. Serving Two Masters: Effect of Escherichia coli Dual Resistance on Antibiotic Susceptibility // Antibiotics (Basel). 2023. Vol. 12, № 3. Art. № 603. https://doi.org/10.3390/antibiotics12030603
Liu G., Liu A., Yang C., Zhou C., Zhou Q., Li H., Yang H., Mo J., Zhang Z., Li G., Si H., Ou C. Portulaca oleracea L. Organic Acid Extract Inhibits Persistent Methicillin Resistant Staphylococcus aureus in vitro and in vivo // Front. Microbiol. 2023. Vol. 13. Art. № 1076154. https://doi.org/10.3389/fmicb.2022.1076154
Guo Y., Yu X., Wang J., Hua D., You Y., Wu Q., Ji Q., Zhang J., Li L., Hu Y., Wu Z., Wei X., Jin L., Meng F., Yang Y., Hu X., Long L., Hu S., Qi H., Ma J., Bei W., Yan X., Wang H., He Z. A Food Poisoning Caused by ST7 Staphylococcal aureus Harboring Sea Gene in Hainan Province, China // Front. Microbiol. 2023. Vol. 14. Art. № 1110720. https://doi.org/10.3389/fmicb.2023.1110720
Bamunusinghage N.P.D., Neelawala R.G., Magedara H.P., Ekanayaka N.W., Kalupahana R.S., Silva-Fletcher A., Kottawatta S.A. Antimicrobial Resistance Patterns of Fecal Escherichia coli in Wildlife, Urban Wildlife, and Livestock in the Eastern Region of Sri Lanka, and Differences Between Carnivores, Omnivores, and Herbivores // J. Wildl. Dis. 2022. Vol. 58, № 2. P. 380–383. https://doi.org/10.7589/jwd-d-21-00048
Carneiro Aguiar R.A., Ferreira F.A., Dias R.S., Nero L.A., Miotto M., Verruck S., De Marco I., De Dea Lindner J. Graduate Student Literature Review: Enterotoxigenic Potential and Antimicrobial Resistance of Staphylococci from Brazilian Artisanal Raw Milk Cheeses // J. Dairy Sci. 2022. Vol. 105, № 7. P. 5685–5699. https://doi.org/10.3168/jds.2021-21634
Abudawood M., Alnuaim L., Tabassum H., Ghneim H.K., Alfhili M.A., Alanazi S.T., Alenzi N.D., Alsobaie S. An Insight into the Impact of Serum Tellurium, Thallium, Osmium and Antimony on the Antioxidant/Redox Status of PCOS Patients: A Comprehensive Study // Int. J. Mol. Sci. 2023. Vol. 24, № 3. Art. № 2596. https://doi.org/10.3390/ijms24032596
Адиева А.А., Климова Р.Р., Абакаров Г.М., Меджидова М.Г., Джамалова С.А., Омарова Д.К., Меджидов М.А. Изучение биологических свойств теллурсодержащих гетероциклических соединений // Междунар. журн. приклад. и фундам. исслед. 2021. № 10. С. 7–11.
Исрапилова А.И., Адиева А.А., Джафарова А.М., Абакаров Г.М., Амирханова И.В. Антибактериальные свойства теллурорганических соединений // Вопр. биол., мед. и фармацевт. химии. 2024. Т. 27, № 2. С. 35−42. https://doi.org/10.29296/25877313-2024-02-0
Адиева А.А., Климова Р.Р., Абакаров Г.М., Бекшоков К.С., Федорова Н.Е., Омарова Д.К., Кущ А.А., Джамалова С.А., Халимбекова А.М., Гусейнова А.Р. Цитотоксичность и противовирусная активность производных теллура в клетках, инфицированных вирусом простого герпеса и цитомегаловирусом in vitro // Юг России: экология, развитие. 2021. Т. 16, № 3. С. 108–118. https://doi.org/10.18470/1992-1098-2021-3-108-118
