Current Ideas About the Regulation of the Activity of Thyroid Hormones and the Mechanism of Their Action at the Cellular Level (Review)
DOI:
https://doi.org/10.37482/2687-1491-Z234Keywords:
thyroid hormones, thyroid gland, triiodothyronine, thyroxine, deiodinases, genomic action, non-genomic actionAbstract
Thyroid hormones (THs) are involved in a number of physiological processes occurring in a living organism. They participate in the regulation of the nervous, respiratory, cardiovascular, muscular, and osteoarticular systems, as well as in the processes of thermogenesis, sleep and wakefulness, and reproductive function, and modulate a number of neurotransmitter systems in the brain. Studying the mechanism of TH action in the body is necessary both to understand the reactions these hormones are involved in and to develop ways to regulate their activity. Based on the results of the analysis of Russian and foreign studies for 2011–2023, in line with the current ideas about the regulation of activity and cellular-level mechanism of action of THs, the review points out the specific features and principles of cellular regulation of THs, describes the processes of TH activation under the action of deiodinase enzymes, and characterizes the biological effect of TH regulation. In addition, the mechanisms of genomic and non-genomic action of THs are presented. It has been shown that the genomic (“classical”) action of THs through modulation of the transcription of specific genes affects the growth, development, differentiation and maintenance of the normal functioning of target tissues. Non-genomic mechanisms of TH action are mediated by the plasma membrane or cytoplasmic receptors and regulate the processes of growth, development and metabolism in the body. At the same time, the non-genomic action of THs can both be realized independently of the genomic action and complement, enhance or inhibit the effects of TH binding to transcriptionally active nuclear receptors during the implementation of TH genomic action. According to the results of the study, TH action at the genomic and non-genomic levels is realized in a complex manner, and it is the interaction between the genomic and nongenomic influence of THs that determines the effectiveness of thyroid regulation of cellular processes.
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Давтян А.Р., Памаев С.В., Давудов И.Т. Исследовательская активность у самок мышей линии СЗН-А на фоне измененного тиреоидного статуса // Смолен. мед. альм. 2019. № 1. С. 87–89.
Kazakou P., Nicolaides N.C., Chrousos G.P. Basic Concepts and Hormonal Regulators of the Stress System // Horm. Res. Paediatr. 2023. Vol. 96, № 1. P. 8–16. https://doi.org/10.1159/000523975
Litwack G. Chapter 5 – Thyroid Hormones // Litwack G. Hormones. London: Academic Press, 2022. P. 101–121. https://doi.org/10.1016/B978-0-323-90262-5.00028-7
Luongo C., Dentice M., Salvatore D. Deiodinases and Their Intricate Role in Thyroid Hormone Homeostasis // Nat. Rev. Endocrinol. 2019. Vol. 15. P. 479–488. https://doi.org/10.1038/s41574-019-0218-2
Tedeschi L., Vassalle C., Iervasi G., Sabatino L. Main Factors Involved in Thyroid Hormone Action // Molecules. 2021. Vol. 26, № 23. Art. № 7337. https://doi.org/10.3390/molecules26237337
Lasa M., Contreras-Jurado C. Thyroid Hormones Act as Modulators of Inflammation Through Their Nuclear Receptors // Front. Endocrinol. 2022. Vol. 13. Art. № 937099. https://doi.org/10.3389/fendo.2022.937099
Cioffi F., Giacco A., Goglia F., Silvestri E. Bioenergetic Aspects of Mitochondrial Actions of Thyroid Hormones // Cells. 2022. Vol. 11, № 6. Art. № 997. https://doi.org/10.3390/cells11060997
Russo S.C., Salas-Lucia F., Bianco A.C. Deiodinases and the Metabolic Code for Thyroid Hormone Action // Endocrinology. 2021. Vol. 162, № 8. Art. № bqab059. https://doi.org/10.1210/endocr/bqab059
Forrest D., Hernandez A. ABCD of Thyroid Hormone Action: After and Before Cloning of Deiodinase Genes // Endocrinology. 2021. Vol. 162, № 10. Art. № bqab151. https://doi.org/10.1210/endocr/bqab151
Bianco A.C., Dumitrescu A., Gereben B., Ribeiro M.O., Fonseca T.L., Fernandes G.W., Bocco B.M.L.C. Paradigms of Dynamic Control of Thyroid Hormone Signaling // Endocr. Rev. 2019. Vol. 40, № 4. P. 1000–1047. https://doi.org/10.1210/er.2018-00275
Al-Suhaimi E.A., Khan F.A. Thyroid Glands: Physiology and Structure // Emerging Concepts in Endocrine Structure and Functions / ed. by E.A. Al-Suhaimi. Singapore: Springer, 2022. P. 133–160. https://doi.org/10.1007/978-981-16-9016-7_5
Mullur R., Liu Y.-Y., Brent G.A. Thyroid Hormone Regulation of Metabolism // Physiol. Rev. 2014. Vol. 94, № 2. P. 355–382. https://doi.org/10.1152/physrev.00030.2013
McDermott M.T. Hypothyroidism // Ann. Intern. Med. 2020. Vol. 173, № 1. P. ITC1–ITC16. https://doi.org/10.7326/AITC202007070
Глушаков Р.И., Прошин С.Н., Тапильская Н.И. Роль тиреоидных гормонов в регуляции ангиогенеза, клеточной пролиферации и миграции // Гены и клетки. 2011. Т. 6, № 4. С. 26–33.
Machado M., Bachini F., Itaborahy A. Thyroid Hormones and Skeletal Muscle Beyond Thermogenesis // J. Sci.Sport Exerc. 2023. Vol. 6. P. 315–323. https://doi.org/10.1007/s42978-023-00235-y
Ma Z., Song P., Ji D., Zheng M., Qiu Z., Liu Z., Wang B. Thyroid Hormones as Biomarkers of Lung Cancer: A Retrospective Study // Ann. Med. 2023. Vol. 55, № 1. https://doi.org/10.1080/07853890.2023.2196088
Visser W.E., Friesema E.C.H., Visser T.J. Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns // Mol. Endocrinol. 2011. Vol. 25, № 1. P. 1–14. https://doi.org/10.1210/me.2010-0095
Sharlin D.S., Visser T.J., Forrest D. Developmental and Cell-Specific Expression of Thyroid Hormone Transporters in the Mouse Cochlea // Endocrinology. 2011. Vol. 152, № 12. P. 5053–5064. https://doi.org/10.1210/en.2011-1372
Bernal J. Thyroid Hormone Transport in Developing Brain // Curr. Opin. Endocrinol. Diabetes Obes. 2011. Vol. 18, № 5. P. 295–299. https://doi.org/10.1097/MED.0b013e32834a78b3
Giammanco M., Di Liegro C.M., Schiera G., Di Liegro I. Genomic and Non-Genomic Mechanisms of Action of Thyroid Hormones and Their Catabolite 3,5-Diiodo-L-Thyronine in Mammals // Int. J. Mol. Sci. 2020. Vol. 21, № 11. Art. № 4140. https://doi.org/10.3390/ijms21114140
Davis P.J., Leonard J.L., Lin H.Y., Leinung M., Mousa S.A. Molecular Basis of Nongenomic Actions of Thyroid Hormone // Vitam. Horm. 2018. Vol. 106. P. 67–96. https://doi.org/10.1016/bs.vh.2017.06.001
Incerpi S., Gionfra F., De Luca R., Candelotti E., De Vito P., Percario Z.A., Leone S., Gnocchi D., Rossi M., Caruso F., Scapin S., Davis P.J., Lin H.Y., Affabris E., Pedersen J.Z. Extranuclear Effects of Thyroid Hormones and Analogs During Development: An Old Mechanism with Emerging Roles // Front. Endocrinol. (Lausanne). 2022. Vol. 13. Art. № 961744. https://doi.org/10.3389/fendo.2022.961744
Almojali A.I., Almalki S.A., Alothman A.S., Masuadi E.M., Alaqeel M.K. The Prevalence and Association of Stress with Sleep Quality Among Medical Students // J. Epidemiol. Glob. Health. 2017. Vol. 7, № 3. P. 169–174. https://doi.org/10.1016/j.jegh.2017.04.005
Маркевич Т.Н., Городецкая И.В. Влияние стресса на уровень йодсодержащих гормонов щитовидной железы // Достижения фундаментальной, клинической медицины и фармации: материалы 76-й науч. сессии ВГМУ. Витебск: Витеб. гос. мед. ун-т, 2021. С. 282–284.
Зябишева В.Н. Актуальность физиологических исследований в условиях Европейского Севера на примере изучения фотопериодической динамики показателей тиреоидного профиля // Журн. мед.-биол. исследований. 2022. Т. 10, № 2. С. 180–183. https://doi.org/10.37482/2687-1491-Z100
Селиванова Е.К., Тарасова О.С. Негеномное действие тиреоидных гормонов: роль в регуляции сосудистой системы // Вестн. Моск. ун-та. Сер. 16: Биология. 2020. Т. 75, № 4. С. 226–236.
Nappi A., Murolo M., Sagliocchi S., Miro C., Cicatiello A.G., Di Cicco E., Di Paola R., Raia M., D’Esposito L., Stornaiuolo M., Dentice M. Selective Inhibition of Genomic and Non-Genomic Effects of Thyroid Hormone Regulates Muscle Cell Differentiation and Metabolic Behavior // Int. J. Mol. Sci. 2021. Vol. 22, № 13. Art. № 7175. https://doi.org/10.3390/ijms22137175
Liu Y.-C., Yeh C.-T., Lin K.-H. Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis // Int. J. Mol. Sci. 2019. Vol. 20, № 20. Art. № 4986. https://doi.org/10.3390/ijms20204986
Lanni A., Moreno M., Goglia F. Mitochondrial Actions of Thyroid Hormone // Compr. Physiol. 2016. Vol. 6, № 4. P. 1591–1607. https://doi.org/10.1002/cphy.c150019
